Department of Cell Biology


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1.  Butel JS, Brugge JS, Noonan CA. Transformation of primate and rodent cells by temperature-sensitive mutants of SV40. Cold Spring Harb Symp Quant Biol. 1975;39 Pt 1:25-36. PMID: 169066

2.  Brugge JS, Butel JS. Role of simian virus 40 gene A function in maintenance of transformation. J Virol. 1975;15(3):619-35. PMCID: 354498.

3.  Vollett J, Brugge JS, and Butel JS.  Temperature-dependent microfilament alterations in cells transformed by group A mutants of SV40. J. Cell. Biol. 67:114 (1975).

4.  Noonan CA, Brugge JS, Butel JS. Characterization of simian cells tranformed by temperature-sensitive mutants of simian virus 40. J Virol. 1976;18(3):1106-19. PMCID: 354810.

5.  Vollet JJ, Brugge JS, Noonan CA, Butel JS. The role of SV40 gene A in the alteration of microfilaments in transformed cells. Exp Cell Res. 1977;105(1):119-26. PMID: 190024

6.  Erikson E, Brugge JS, Erikson RL. Phosphorylated and nonphosphorylated forms of avian sarcoma virus polypeptide p19. Virology. 1977;80(1):177-85. PMID: 195394

7.  Brugge JS, Erikson RL. Identification of a transformation-specific antigen induced by an avian sarcoma virus. Nature. 1977;269(5626):346-8. PMID: 198667

8.  Brugge JS, Purchio AF, Erikson RL. Virus-specific RNA species present in the cytoplasm of Rous sarcoma virus-infected chicken cells. Virology. 1977;83(1):16-26. PMID: 18625472

9.  Brugge JS, Purchio AF, Erikson RL. The distribution of virus-specific RNA in Rous sarcoma virus-induced hamster tumor cells. Virology. 1977;83(1):27-33. PMID: 18625473

10.  Brugge JS, Erikson E, Erikson RL. Antibody to virion structural proteins in mammals bearing avian sarcoma virus-induced tumors. Virology. 1978;84(2):429-33. PMID: 74898

11.  Purchio AF, Erikson E, Brugge JS, Erikson RL. Identification of a polypeptide encoded by the avian sarcoma virus src gene. Proc Natl Acad Sci U S A. 1978;75(3):1567-71. PMCID: 411515.

12.  Brugge JS, Erikson E, Collett M, Erikson RL.  Peptide analysis of the transformation-specific antigen from avian sarcoma virus-transformed cells. J. Virol. 26:773 (1978). PMCID: 525902

13.  Brugge JS, Steinbaugh PJ, Erikson RL. Characterization of the avian sarcoma virus protein p60src. Virology. 1978;91(1):130-40. PMID: 214955

14.  Collett MS, Brugge JS, Erikson RL. Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product. Cell. 1978;15(4):1363-9. PMID: 83198

15.  Brugge JS, Collett MS, Siddiqui A, Marczynska B, Deinhardt F, Erikson RL. Detection of the viral sarcoma gene product in cells infected with various strains of avian sarcoma virus and of a related protein in uninfected chicken cells. J Virol. 1979;29(3):1196-203. PMCID: 353280.

16.  Collett MS, Erikson E, Purchio AF, Brugge JS, Erikson RL. A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product. Proc Natl Acad Sci U S A. 1979;76(7):3159-63. PMCID: 383783.

17.  Collett MS, Brugge JS, Erikson RL, Lau AF, Krzyzek RA, Faras AJ. The src gene product of transformed and morphologically reverted ASV-infected mammalian cells. Nature. 1979;281(5728):195-8. PMID: 225672

18.  Lau AF, Krzyzek RA, Brugge JS, Erikson RL, Schollmeyer J, Faras AJ. Morphological revertants of an avian sarcoma virus-transformed mammalian cell line exhibit tumorigenicity and contain pp60src. Proc Natl Acad Sci U S A. 1979;76(8):3904-8. PMCID: 383944.

19.  Erikson RI, Collett MS, Erikson E, Purchio AF, Brugge JS. Protein phosphorylation mediated by partially purified avian sarcoma virus transforming-gene product. Cold Spring Harb Symp Quant Biol. 1980;44 Pt 2:907-17. PMID: 6253222

20.  Erikson RL, Purchio AF, Erikson E, Collett MS, Brugge JS. Molecular events in cells transformed by Rous Sarcoma virus. J Cell Biol. 1980;87(2 Pt 1):319-25. PMCID: 2110755.

21.  Brugge JS, Erikson E, Erikson RL. The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins. Cell. 1981;25(2):363-72. PMID: 6269742

22.  Brugge JS, Darrow D. Rous sarcoma virus-induced phosphorylation of a 50,000-molecular weight cellular protein. Nature. 1982;295(5846):250-3. PMID: 6276771

23.  Lipsich LA, Cutt JR, Brugge JS. Association of the transforming proteins of Rous, Fujinami, and Y73 avian sarcoma viruses with the same two cellular proteins. Mol Cell Biol. 1982;2(7):875-80. PMCID: 369870.

24.  Brugge JS, Yonemoto W, Darrow D.  Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: Analysis of the turnover and distribution of this complex. Mol. Cell. Biol. 3:9 (1983). PMID: 6298609

25.  Lanks KW, Kasambalides EJ, Chinkers M, Brugge JS. A major cytoplasmic glucose-regulated protein is associated with the Rous sarcoma virus pp60src protein. J Biol Chem. 1982;257(15):8604-7. PMID: 6807976

26.  Cotton PC, Brugge JS. Neural tissues express high levels of the cellular src gene product pp60c-src. Mol Cell Biol. 1983;3(6):1157-62. PMCID: 368645.

27.  Lipsich LA, Lewis AJ, Brugge JS. Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses. J Virol. 1983;48(2):352-60. PMCID: 255359.

28.  Keane RW, Lipsich LA, Brugge JS. Differentiation and transformation of neural plate cells. Dev Biol. 1984;103(1):38-52. PMID: 6201407

29.  Brugge JS, Darrow D. Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins. J Biol Chem. 1984;259(7):4550-7. PMID: 6323478

30.  Chinkers M, Brugge JS. Characterization of structural domains of the human epidermal growth factor receptor obtained by partial proteolysis. J Biol Chem. 1984;259(18):11534-42. PMID: 6088549

31.  Lipsich L, Brugge JS, Boettiger D. Expression of the Rous sarcoma virus src gene in avian macrophages fails to elicit transformed cell phenotype. Mol Cell Biol. 1984;4(7):1420-4. PMCID: 368926.

32.  Bolen JB, Thiele CJ, Israel MA, Yonemoto W, Lipsich LA, Brugge JS. Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation. Cell. 1984;38(3):767-77. PMID: 6091900

33.  Hughes S, Mellstrom K, Kosik E, Tamanoi F, Brugge JS.  Mutation of a termination codon affects src initiation.  Mol. Cell. Bio. 4:1738-1746 (1984). PMCID: 368891

34.  Yonemoto W, Jarvis-Morar M, Brugge JS, Bolen JB, Israel MA. Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen. Proc Natl Acad Sci U S A. 1985;82(14):4568-72. PMCID: 390426.

35.  Brugge JS, Cotton PC, Queral AE, Barrett JN, Nonner D, Keane RW. Neurones express high levels of a structurally modified, activated form of pp60c-src. Nature. 1985;316(6028):554-7. PMID: 2412121

36.  Schuh SM, Brugge JS. Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527. Mol Cell Biol. 1988;8(6):2465-71. PMCID: 363446.

37.  Golden A, Nemeth SP, Brugge JS. Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity. Proc Natl Acad Sci U S A. 1986;83(4):852-6. PMCID: 322968.

38.  Lynch SA, Brugge JS, Levine JM. Induction of altered c-src product during neural differentiation of embryonal carcinoma cells. Science. 1986;234(4778):873-6. PMID: 3095923

39.  Yonemoto W, Filson AJ, Queral-Lustig AE, Wang JY, Brugge JS. Detection of phosphotyrosine-containing proteins in polyomavirus middle tumor antigen-transformed cells after treatment with a phosphotyrosine phosphatase inhibitor. Mol Cell Biol. 1987;7(2):905-13. PMCID: 365149.

40.  Brugge JS, Jarosik G, Andersen J, Queral-Lustig A, Fedor-Chaiken M, Broach JR. Expression of Rous sarcoma virus transforming protein pp60v-src in Saccharomyces cerevisiae cells. Mol Cell Biol. 1987;7(6):2180-7. PMCID: 365341.

41.  Brugge JS, Cotton PM, Lustig A, Yonemoto W, Lipsich LA,  Coussens PM, Barrett JN, Nonner D, Keane RWCharacterization of the altered form of the c-src gene product in neuronal cells. Genes & Dev. 1:287-296 (1987). PMID: 2445628

42.  Brugge JS, Lustig A, Messer A. Changes in the pattern of expression of pp60c-src in cerebellar mutants of mice. J Neurosci Res. 1987;18(4):532-8. PMID: 3125343

43.  Levy JB, Dorai T, Wang LH, Brugge JS. The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA. Mol Cell Biol. 1987;7(11):4142-5. PMCID: 368089.

44.  Walaas SI, Lustig A, Greengard P, Brugge JS. Widespread distribution of the c-src gene product in nerve cells and axon terminals in the adult rat brain. Brain Res. 1988;427(3):215-22. PMID: 3042087

45.  Schuh SM, Brugge JS. Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527. Mol Cell Biol. 1988;8(6):2465-71. PMCID: 363446.

46.  Lundy J, Chen J, Wang P, Fromowitz F, Schuss A, Lynch S.,  Brugge JS, Viola MVPhenotypic and genetic alterations in pre-cancerous cells in the colon. Anticancer Research 8:1005-1014  (1988). PMID: 3052255

47.  Golden A, Brugge JS. Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets. Proc Natl Acad Sci U S A. 1989;86(3):901-5. PMCID: 286586.

48.  Nemeth SP, Fox LG, DeMarco M, Brugge JS. Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein. Mol Cell Biol. 1989;9(3):1109-19. PMCID: 362701.

49.  Levy JB, Brugge JS. Biological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts. Mol Cell Biol. 1989;9(8):3332-41. PMCID: 362378.

50.  Ferracini R, Brugge JS.  Analysis of mutant forms of the c-src gene product containing a phenylalanine substitution for tyrosine 416.  Oncogene Research 5:205-219 (1990). PMID: 1690870

51.  Sugrue MM, Brugge JS, Marshak DR, Greengard P, Gustafson EL. Immunocytochemical localization of the neuron-specific form of the c-src gene product, pp60c-src(+), in rat brain. J Neurosci. 1990;10(8):2513-27. PMID: 1696980

52.  Golden A, Brugge JS, Shattil SJ. Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins. J Cell Biol. 1990;111(6 Pt 2):3117-27. PMCID: 2116418.

53.  Filson AJ, Azarnia R, Beyer EC, Loewenstein WR, Brugge JS. Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication. Cell Growth Differ. 1990;1(12):661-8. PMID: 1963075

54.  Mitchell CA, Jefferson AB, Bejeck BE, Brugge JS, Deuel TF, Majerus PW. Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets. Proc Natl Acad Sci U S A. 1990;87(23):9396-400. PMCID: 55172.

55.  Lord KA, Abdollahi A, Thomas SM, DeMarco M, Brugge JS, Hoffman-Liebermann B, Liebermann DA. Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation. Mol Cell Biol. 1991;11(9):4371-9. PMCID: 361299.

56.  Thomas SM, Hayes M, D'Arcangelo G, Armstrong RC, Meyer BE, Zilberstein A, Brugge JS, Halegoua S. Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation. Mol Cell Biol. 1991;11(9):4739-50. PMCID: 361372.

57.  Dorai T, Levy JB, Kang L, Brugge JS, Wang LH. Analysis of cDNAs of the proto-oncogene c-src: heterogeneity in 5' exons and possible mechanism for the genesis of the 3' end of v-src. Mol Cell Biol. 1991;11(8):4165-76. PMCID: 361236.

58.  Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. Proc Natl Acad Sci U S A. 1991;88(17):7844-8. PMCID: 52400.

59.  Kremer NE, D'Arcangelo G, Thomas SM, DeMarco M, Brugge JS, Halegoua S. Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions. J Cell Biol. 1991;115(3):809-19. PMCID: 2289191.

60.  Thomas JE, Soriano P, Brugge JS. Phosphorylation of c-Src on tyrosine 527 by another protein tyrosine kinase. Science. 1991;254(5031):568-71. PMID: 1719633

61.  Schmidt JW, Brugge JS, Nelson WJ. pp60src tyrosine kinase modulates P19 embryonal carcinoma cell fate by inhibiting neuronal but not epithelial differentiation. J Cell Biol. 1992;116(4):1019-33. PMCID: 2289338.

62.  Huang MM, Indik Z, Brass LF, Hoxie JA, Schreiber AD, Brugge JS. Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII. J Biol Chem. 1992;267(8):5467-73. PMID: 1372004

63.  Cichowski K, McCormick F, Brugge JS. p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. J Biol Chem. 1992;267(8):5025-8. PMID: 1544885

64.  Seidel-Dugan C, Meyer BE, Thomas SM, Brugge JS. Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src. Mol Cell Biol. 1992;12(4):1835-45. PMCID: 369627.

65.  Thomas SM, DeMarco M, D'Arcangelo G, Halegoua S, Brugge JS. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell. 1992;68(6):1031-40. PMID: 1312392

66. Maroney AC, Qureshi SA, Foster DA, Brugge JS. Cloning and characterization of a thermolabile v-src gene for use in reversible transformation of mammalian cells. Oncogene. 1992;7(6):1207-14. PMID: 1375718

67. Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT, Brugge JS. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J Cell Biol. 1992;119(4):905-12. PMCID: 2289696.

68.  Yu H, Rosen MK, Shin TB, Seidel-Dugan C, Brugge JS, Schreiber SL. Solution structure of the SH3 domain of Src and identification of its ligand-binding site. Science. 1992;258(5088):1665-8. PMID: 1280858

69.  Rozakis-Adcock M, McGlade J, Mbamalu G, Pelicci G, Daly R, Li W, Batzer A, Thomas S, Brugge JS, Pelicci PG, Schlessinger J, Pawson T.  Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature 360: 689-692 (1992). PMID: 1465135

70.  Clark EA, Brugge JS. Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets. Mol Cell Biol. 1993;13(3):1863-71. PMCID: 359499.

71.  Fox JE, Lipfert L, Clark EA, Reynolds CC, Austin CD, Brugge JS. On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton. J Biol Chem. 1993;268(34):25973-84. PMID: 7503992

72.  Haimovich B, Lipfert L, Brugge JS, Shattil SJ. Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. J Biol Chem. 1993;268(21):15868-77. PMID: 8340412

73.  Thomas JE, Aguzzi A, Soriano P, Wagner EF, Brugge JS. Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src. Oncogene. 1993;8(9):2521-9. PMID: 7689725

74.  Weng Z, Taylor JA, Turner CE, Brugge JS, Seidel-Dugan C. Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells. J Biol Chem. 1993;268(20):14956-63. PMID: 8325872

75.  Lynch SA, Brugge JS, Fromowitz F, Glantz L, Wang P, Caruso R, Viola MV. Increased expression of the src proto-oncogene in hairy cell leukemia and a subgroup of B-cell lymphomas. Leukemia. 1993;7(9):1416-22. PMID: 7690441

76.  Huang MM, Lipfert L, Cunningham M, Brugge JS, Ginsberg MH, Shattil SJ. Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J Cell Biol. 1993;122(2):473-83. PMCID: 2119653.

77.  Shattil SJ, Haimovich B, Cunningham M, Lipfert L, Parsons JT, Ginsberg MH, Brugge JS. Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors. J Biol Chem. 1994;269(20):14738-45.(1) PMID: 7514181

78.  Weng Z, Thomas SM, Rickles RJ, Taylor JA, Brauer AW, Seidel-Dugan C, Michael WM, Dreyfuss G, Brugge JS. Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains. Mol Cell Biol. 1994;14(7):4509-21. PMCID: 358823.

79.  Clark EA, Shattil SJ, Ginsberg MH, Bolen J, Brugge JS. Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. J Biol Chem. 1994;269(46):28859-64. PMID: 7961845

80.  Clark EA, Trikha M, Markland FS, Brugge JS. Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation. J Biol Chem. 1994;269(35):21940-3. PMID: 7520909

81.  Rickles RJ, Botfield MC, Weng Z, Taylor JA, Green OM, Brugge JS, Zoller MJ. Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries. EMBO J. 1994;13(23):5598-604. PMCID: 395523.

82.  Shiue L, Green J, Green OM, Karas JL, Morgenstern JP, Ram MK. Taylor MK, Zoller MJ, Zydowsky LD, Bolen JB, Brugge JS.  Interaction of p72syk with the g and b subunits of the high-affinity receptor for immunoglobulin E, FcERI.  Mol. Cell. Biol. 15: 272-281 (1995).

83.  Rivera VM, Brugge JS. Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells. Mol Cell Biol. 1995;15(3):1582-90. PMCID: 230382.

84.  Shiue L, Zoller MJ, Brugge JS. Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE. J Biol Chem. 1995;270(18):10498-502. PMID: 7637732

85.  Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature. 1995;375(6532):577-81 PMID: 7540725

86.  Weng Z, Rickles RJ, Feng S, Richard S, Shaw AS, Schreiber SL, Brugge JS. Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions. Mol Cell Biol. 1995;15(10):5627-34. PMCID: 230813.

87.  Rickles RJ, Botfield MC, Zhou XM, Henry PA, Brugge JS, Zoller MJ. Phage display selection of ligand residues important for Src homology 3 domain binding specificity. Proc Natl Acad Sci U S A. 1995;92(24):10909-13. PMCID: 40540.

88.  Rusanescu G, Qi H, Thomas SM, Brugge JS, Halegoua S. Calcium influx induces neurite growth through a Src-Ras signaling cassette. Neuron. 1995;15(6):1415-25. PMID: 8845164

89.  Cichowski K, Brugge JS, Brass LF. Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets. J Biol Chem. 1996;271(13):7544-50. PMID: 8631786

90.  Zoller KE, MacNeil IA, Brugge JS. Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction. J Immunol. 1997;158(4):1650-9. PMID: 9029101

91.  King WG, Mattaliano MD, Chan TO, Tsichlis PN, Brugge JS. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol Cell Biol. 1997;17(8):4406-18. PMCID: 232295.

92. Gao J, Zoller KE, Ginsberg MH, Brugge JS, Shattil SJ. Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. EMBO J. 1997;16(21):6414-25. PMCID: 1170248.

93.  Clark EA, King WG, Brugge JS, Symons M, Hynes RO. Integrin-mediated signals regulated by members of the rho family of GTPases. J Cell Biol. 1998;142(2):573-86. PMCID: 2133065.

94. Miranti CK, Leng L, Maschberger P, Brugge JS, Shattil SJ. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr Biol. 1998;8(24):1289-99. PMID: 9843681

95. Miranti CK, Ohno S, Brugge JS. Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc. J Biol Chem. 1999;274(15):10571-81. PMID: 10187852

96. Muthuswamy SK, Gilman M, Brugge JS. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol. 1999;19(10):6845-57. PMCID: 84681.

97. Rao VR, Corradetti MN, Chen J, Peng J, Yuan J, Prestwich GD, Brugge JS. Expression cloning of protein targets for 3-phosphorylated phosphoinositides. J Biol Chem. 1999;274(53):37893-900. PMID: 10608855

98. Chaudhary A, King WG, Mattaliano MD, Frost JA, Diaz B, Morrison DK, Cobb MH, Marshall MS, Brugge JS. Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr Biol. 2000;10(9):551-4. PMID: 10801448

99. Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W. Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol. 2000;20(17):6364-73. PMCID: 86111.

100. Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol. 2001;3(9):785-92. PMCID: 2952547.

101. Woodside DG, Obergfell A, Leng L, Wilsbacher JL, Miranti CK, Brugge JS, Shattil SJ, Ginsberg MH. Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains. Curr Biol. 2001;11(22):1799-804.

102. Chaudhary A, Brugge JS, Cooper JA. Direct phosphorylation of focal adhesion kinase by c-Src: evidence using a modified nucleotide pocket kinase and ATP analog. Biochem Biophys Res Commun. 2002;294(2):293-300.

 103. Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002;157(2):265-75. PMCID: 2199242.

104. Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell. 2002;111(1):29-40.

105.  Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003;30(3):256-68.

106. Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol. 2003;5(8):733-40.

107. Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003;114(1):99-111.

108. Debnath J, Walker SJ, Brugge JS. Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol. 2003;163(2):315-26. PMCID: 2173511.

109. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A. 2003;100(23):13298-302. PMCID: 263791.

110. Fujikawa, K., Miletic, A.V., Alt, FW, Faccio, R, Brown, T. , Hoog. J, Fredericks, J., Nichi, S, Mildiner, S. Moores, S. Brugge, JS, Rosen, F, Swat, W. Vav1/2/3-Null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells. J. Exp. Med. 198: 1595-608. (2003).

111. Seton-Rogers SE, Lu Y, Hines LM, Koundinya M, LaBaer J, Muthuswamy SK, Brugge JS. Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc Natl Acad Sci U S A. 2004;101(5):1257-62. PMCID: 337040.

112Mills KR, Reginato M, Debnath J, Queenan B, Brugge JS. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A. 2004;101(10):3438-43. PMCID: 373480.

113. Wrobel CN, Debnath J, Lin E, Beausoleil S, Roussel MF, Brugge JS. Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol. 2004;165(2):263-73. PMCID: 2172030.

114. Bill HM, Knudsen B, Moores SL, Muthuswamy SK, Rao VR, Brugge JS, Miranti CK. Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol. 2004;24(19):8586-99. PMCID: 516761.

115. Martin SS, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS, Leder P. A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene. 2004;23(26):4641-5.

116. Gakidis MA, Cullere X, Olson T, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T, Brugge JS. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004;166(2):273-82. PMCID: 2172310.

117.  Ma X, Wang  Z, Ryan  PD, Isakoff  SI, Barmettler A,  Fuller A, Muir  B, Mohapatra  G, Salunga R, Tuggle JT, Tran Y, Tran  D, Sollberger  A, Amon  P, Wang  W,  Wang  W,  Stecker  K, Estepa-Sabal E, Smith B, Younger J,  Balis  U, Bhan  A, Habin K,  Baer TM, Brugge  JS, Haber  DA, Erlander  MG, Sgroi DC. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.Cancer Cell  5:607-16 (2004).

118. Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK, Brugge JS. Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol. 2005;25(11):4591-601. PMCID: 1140636.

119. Collins NL, Reginato MJ, Paulus JK, Sgroi DC, Labaer J, Brugge JS. G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression. Mol Cell Biol. 2005;25(12):5282-91. PMCID: 1140593.

120. Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 2005;46(2):205-17.

121. Yan SR, Joseph RR, Rosen K, Reginato MJ, Jackson A, Allaire N, Brugge JS, Jobin C, Stadnyk AW. Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. Oncogene. 2005;24(43):6482-91. PMCID: 1509103.

122. Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res. 2005;65(23):10992-1000.

123. Gunawardane RN, Sgroi DC, Wrobel CN, Koh E, Daley GQ, Brugge JS. Novel role for PDEF in epithelial cell migration and invasion. Cancer Res. 2005;65(24):11572-80.

124. Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol. 2005;171(6):1023-34. PMCID: 2171329.

125. Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA, Brugge JS, Ellisen LW. p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol. 2006;8(6):551-61.

126. Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity. 2006;24(3):305-16.

127. Witt AE, Hines LM, Collins NL, Hu Y, Gunawardane RN, Moreira D, Raphael J, Jepson D, Koundinya M, Rolfs A, Taron B, Isakoff SJ, Brugge JS, LaBaer J. Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer. J Proteome Res. 2006;5(3):599-610. PMCID: 2522320.

128. Wilsbacher JL, Moores SL, Brugge JS. An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand. Cell Commun Signal. 2006;4:5. PMCID: 1524963.

129. Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A. 2006;103(33):12405-10. PMCID: 1533802.

130. Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell. 2007;12(2):221-34. PMCID: 2698712.

131. Schmelzle T, Mailleux AA, Overholtzer M, Carroll JS, Solimini NL, Lightcap ES, Veiby OP, Brugge JS. Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc Natl Acad Sci U S A. 2007;104(10):3787-92. PMCID: 1820662.

132. Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA. Common effector processing mediates cell-specific responses to stimuli. Nature 448 (7153): 604-8, 2007.

133. Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 131 (5): 966-79, 2007.

134. Fischbach C, Chen R, Matsumoto T, Schmelzle T, Brugge JS, Polverini PJ, Mooney DJ. Engineering tumors with 3D scaffolds. Nat Methods 4 (10): 855-60, 2007.

135. Melani M, Simpson KJ, Brugge JS, Montell D. Regulation of Cell Adhesion and Collective Cell Migration by Hindsight and Its Human Homolog RREB1. Curr Biol 18 (7): 532-7, 2008.

136. Simpson KJ, Selfors LM, Bui J, Reynolds A, Leake D, Khvorova A, Brugge JS. Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat Cell Biol. 2008;10(9):1027-38.

137. Tamimi RM, Brugge JS, Freedman ML, Miron A, Iglehart JD, Colditz GA, Hankinson SE. Circulating colony stimulating factor-1 and breast cancer risk. Cancer Res. 2008;68(1):18-21. PMCID: 2821592.

138. Konecny GE, Glas R, Dering J, Manivong K, Qi J, Finn RS, Yang GR, Hong KL, Ginther C, Winterhoff B, Gao G, Brugge J, Slamon DJ. Activity of the multikinase inhibitor dasatinib against ovarian cancer cells. Br J Cancer. 2009;101(10):1699-708. PMCID: 2778533.

139. Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH. Mutant p53 drives invasion by promoting integrin recycling. Cell. 2009;139(7):1327-41.

140. Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 2009;461(7260):109-13.

141. Xian W, Pappas L, Pandya D, Selfors LM, Derksen PW, de Bruin M, Gray NS, Jonkers J, Rosen JM, Brugge JS. Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival. Cancer Res. 2009;69(6):2244-51.

142. Zhang J, Ji JY, Yu M, Overholtzer M, Smolen GA, Wang R, Brugge JS, Dyson NJ, Haber DA. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol. 2009;11(12):1444-50. PMCID: 2819909.

143. Janes KA, Wang CC, Holmberg KJ, Cabral K, Brugge JS. Identifying single-cell molecular programs by stochastic profiling. Nat Methods. 2010;7(4):311-7. PMCID: 2849806.

144. Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A. 2010;107(11):5012-7. PMCID: 2841923.

145. Tushir JS, Clancy J, Warren A, Wrobel C, Brugge JS, D'Souza-Schorey C. Unregulated ARF6 Activation in Epithelial Cysts Generates Hyperactive Signaling Endosomes and Disrupts Morphogenesis. Mol Biol Cell. 2010. PMCID: 2893997.

146. Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S. MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A. 2010;107(8):3698-703. PMCID: 2840447.

147. Zhou W, Hur W, McDermott U, Dutt A, Xian W, Ficarro SB, Zhang J, Sharma SV, Brugge J, Meyerson M, Settleman J, Gray NS. A structure-guided approach to creating covalent FGFR inhibitors. Chem Biol. 2010;17(3):285-95.

148. Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS. PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One. 2010;5(7):e11729. PMCID: 2909213.

149. Knowlton ML, Selfors LM, Wrobel CN, Gu TL, Ballif BA, Gygi SP, Polakiewicz R, Brugge JS. Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. PLoS One. 2010;5(10):e13587. PMCID: 2964295.

150. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet 2011 Jul 31;43(9):869-74.

151. Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince T, Brugge JS. Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium. Cancer Discovery. July 2011 1:144-157.

152. Grassian AR, Schafer ZT, Brugge JS. ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells. J Biol Chem. 2011;286(1):79-90. PMCID: 3013038.

153. Kim JH, Cho A, Yin H, Schafer DA, Mouneimne G, Simpson KJ, et al. Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes Dev. 2011;25(7):730-41. PMCID: 3070935.

154. Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, et al. A non-genetic route to aneuploidy in human cancers. Nat Cell Biol. 2011;13(3):324-30.

155. Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev. 2011;25(16):1716-33.

156. Wang L, Brugge JS, Janes KA. Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proc Natl Acad Sci U S A. 2011;108(40):E803-12. PMCID: 3189061.

157. Davidowitz RA, Iwanicki MP,  Brugge JS.  In vitro Mesothelial Clearance Assay that Models the Early Steps of Ovarian Cancer Metastasis. J Vis Exp. 2012(60).

158. Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG. Akt and ERK Control the Proliferative Response of Mammary Epithelial Cells to the Growth Factors IGF-1 and EGF Through the Cell Cycle Inhibitor p57Kip2. Sci Signal. 2012;5(214):ra19.

159. Muranen, T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB and Brugge JS, Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells. Cancer Cell, 2012  21(2):227-39

160. Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS. Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell. 2012;22(5):615-30. PMCID: 3500527.

161. Leung, C and Brugge JS. Outgrowth of Single Oncogene-expressing Cells from Suppressive Epithelial Environments. Nature, 2012  482(7385):410-3

162. Ng MR, Besser A, Danuser G, Brugge JS. Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J Cell Biol. 2012;199(3):545-63. PMCID: 3483134.

163. Albeck JG, Mills GB, Brugge JS. Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals. Molecular Cell. 2013;49(2):249-61.

164. Buchwalter, G, Hickey, M, Cromer, C, Selfors,LM, Gunawardane, RN, Frishman, J., Jeselsohn, R, Lim, E, Chi, D, Fu, X, , Schiff, R, Brown, M, Brugge, JS. PDEF Promotes Luminal Differentiation and Acts as a Survival Factor for ER-Positive Breast Cancer Cells Cancer Cell 201323: 753–767.

165. Kaanta AS, Virtanen C, Selfors L, Brugge JS, Neel BG. Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Research. 2013 Aug 15;15(4):R65

166. Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. Chaperone-mediated autophagy degrades mutant p53. Genes Dev. 2013 Aug 1;27(15):1718-30.

167. Davidowitz RA, Selfors, RM, Iwanicki MP, Karst A, Piao H, Ince TA, Drage MG, Dering J, Konecny GE,  Matulonis U, Mills GB, Slamon D, Drapkin R, Brugge JS Mesenchymal Gene Program Expressing Ovarian Cancer Spheroids Exhibit Mesenchymal Clearance, J Clin Invest. 2014 Jun;124(6):2611-25. PMCID: PMC4038562

168. Ng MR., Besser A, Brugge JS, Danuser G.  Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters. Elife. 2014 Dec 5  PMCID: PMC4311494

169. Godinho SA, Picone R, Burute  M, Regina Dagher R, Ying Su Y, Leung CT, Kornelia Polyak K, Brugge JS, Thery M, and Pellman D.  Oncogene-like induction of cellular invasion from centrosome amplification. Nature 2014:  510:167-71

170. Ince TA, Sousa AD, Jones MA, Harrell JC, Agoston ES, Krohn M, Selfors LM, Liu W, Chen K, Yong M, Buchwald P, Wang B, Hale KS, Cohick E, Sergent P, Witt A, Kozhekbaeva Z, Gao S, Agoston AT, Merritt MA, Foster R, Rueda BR, Crum CP, Brugge JS, Mills GB. Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.  Nat Commun. 2015 Jun 17;6:7419. PMCID: PMC4473807

171. Bui AD, Lee W, White AE, Harper JW, Shcackmann RCJ, Overholtzer M, Selfors LM, Brugge JS. Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP. Science Signaling 2016 Mar 1, 9:417 PMID: 26933062 

172. Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS. Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells. Cell Metabolism 2016 May 10;23(5):867-80. 

173. Gallegos LL, Ng MR, Sowa ME, Selfors LM, White A, Zervantonakis IK, Singh P, Dhakal S, Harper JW, Brugge JS. A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin. Sci Rep. 2016 Jun 3;6:27114. PMID: 27255161

174. Stover DG, Coloff JL, Barry WT, Brugge JS, Winer EP, Selfors LM. The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis. Clin Cancer Res. 2016 Dec 15;22(24):6039-6050. PMID: 27330058

175. Iwanicki MP, Chen HY, Iavarone C, Zervantonakis IK, Muranen T, Novak M, Ince TA, Drapkin R, Brugge JS. Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition. JCI Insight. 2016 Jul 7;1(10). PMID: 27482544

176. Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS. ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP. Cancer Res. 2016 Dec 15;76(24):7168-7180. PMID: 27913436

177. Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf GM, English J, Kirschmeier PT, Velculescu VE, Paweletz C, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R. Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics. Clin Cancer Res. 2017 Mar 1;23(5):1263-1273. PMID: 27573169

178. Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017 Jan 10;8:13989. PMID: 28071763

179. Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS. Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo. NPJ Breast Cancer. 2017 May 1;3:18. PMID: 28649658

180. Zervantonakis IK, Iavarone C, Chen HY, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis U, Leverson JD, Sampath D, Mills GB, Brugge JS. Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response. Nat Commun. 2017 Aug 28;8(1):365. PMID: 28848242

181. Wang Y, Woehrstein JB, Donoghue N, Dai M, Avendaño MS, Schackmann RCJ, Zoeller JJ, Wang SSH, Tillberg PW, Park D, Lapan SW, Boyden ES, Brugge JS, Kaeser PS, Church GM, Agasti SS, Jungmann R, Yin P. Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues. Nano Lett. 2017 Oct 11;17(10):6131-6139. PMID: 28933153

182. Selfors LM, Stover DG, Harris IS, Brugge JS, Coloff JL. Identification of cancer genes that are independent of dominant proliferation and lineage programs. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11276-E11284. PMID: 29229826

183. Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife. 2017 Dec 14;6. pii: e27293. doi: 10.7554/eLife.27293. PMID: 29239720

184. Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS. Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Cancer Cell. 2018 Jun 11;33(6):985-1003.e7. PMID: 29805077

185. Iavarone C, Zervantonakis IK, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis UA, Hallberg D, Velculescu VE, Leverson JD, Sampath D, Mills GB, Brugge JS. Combined MEK and BCL-2/XL inhibition is effective in high-grade serous ovarian cancer patient-derived xenograft models and BIM levels are predictive of responsiveness. Mol Cancer Ther. 2019 Jan 24. pii: molcanther.0413.2018. PMID: 30835824 

186. Zoeller JJ, Vagodny A, Taneja K, Tan BY, O'Brien N, Slamon DJ, Sampath D, Leverson JD, Bronson RT, Dillon DA, Brugge JS. Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo. Mol Cancer Ther. 2019 Jun;18(6):1115-1126. PMID: 30962322 

187. Press MF, Xie B, Davenport S, Zhou Y, Guzman R, Nolan GP, O'Brien N, Palazzolo M, Mak TW, Brugge JS, Slamon DJ. Role for polo-like kinase 4 in mediation of cytokinesis. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11309-11318. PMID: 31097597

188. Rosenbluth JM, Schackmann RCJ, Gray GK, Selfors LM, Li CM, Boedicker M, Kuiken HJ, Richardson A, Brock J, Garber J, Dillon D, Sachs N, Clevers H, Brugge JS. Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages. Nat Commun. 2020 Apr 6;11(1):1711. PMID: 32249764

189. Shu S, Wu HJ, Ge JY, Zeid R, Harris IS, Jovanović B, Murphy K, Wang B, Qiu X, Endress JE, Reyes J, Lim K, Font-Tello A, Syamala S, Xiao T, Reddy Chilamakuri CS, Papachristou EK, D'Santos C, Anand J, Hinohara K, Li W, McDonald TO, Luoma A, Modiste RJ, Nguyen QD, Michel B, Cejas P, Kadoch C, Jaffe JD, Wucherpfennig KW, Qi J, Liu XS, Long H, Brown M, Carroll JS, Brugge JS, Bradner J, Michor F, Polyak K. Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. Mol Cell. 2020 Jun 18;78(6):1096-1113.e8. PMID: 32416067

190. Zervantonakis IK, Poskus MD, Scott AL, Selfors LM, Lin JR, Dillon DA, Pathania S, Sorger PK, Mills GB, Brugge JS. Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16500-16508. PMID: 32601199

191. Takahashi N, Cho P, Selfors LM, Kuiken HJ, Kaul R, Fujiwara T, Harris IS, Zhang T, Gygi SP, Brugge JS. 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis. Mol Cell. 2020 Oct 26:S1097-2765(20)30693-6. PMID: 33128871

192. Zhao W, Li J, Chen MM, Luo Y, Ju Z, Nesser NK, Johnson-Camacho K, Boniface CT, Lawrence Y, Pande NT, Davies MA, Herlyn M, Muranen T, Zervantonakis IK, von Euw E, Schultz A, Kumar SV, Korkut A, Spellman PT, Akbani R, Slamon DJ, Gray JW, Brugge JS, Lu Y, Mills GB, Liang H. Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines. Cancer Cell. 2020 Oct 26:S1535-6108(20)30539-0. PMID: 33157050

193. Naffar-Abu Amara S, Kuiken HJ, Selfors LM, Butler T, Leung ML, Leung CT, Kuhn EP, Kolarova T, Hage C, Ganesh K, Panayiotou R, Foster R, Rueda BR, Aktipis A, Spellman P, Ince TA, Xiu J, Oberley M, Gatalica Z, Navin N, Mills GB, Bronson RT, Brugge JS. Transient commensal clonal interactions can drive tumor metastasis. Nat Commun. 2020 Nov 16;11(1):5799. PMID: 33199705

194. Hurvitz SA, Caswell-Jin JL, McNamara KL, Zoeller JJ, Bean GR, Dichmann R, Perez A, Patel R, Zehngebot L, Allen H, Bosserman L, DiCarlo B, Kennedy A, Giuliano A, Calfa C, Molthrop D, Mani A, Chen HW, Dering J, Adams B, Kotler E, Press MF, Brugge JS, Curtis C, Slamon DJ. Pathologic and molecular responses to neoadjuvant trastuzumab and/or lapatinib from a phase II randomized trial in HER2-positive breast cancer (TRIO-US B07). Nat Commun. 2020 Nov 17;11(1):5824. PMID: 33203854

195. Zoeller JJ, Vagodny A, Daniels VW, Taneja K, Tan BY, DeRose YS, Fujita M, Welm AL, Letai A, Leverson JD, Blot V, Bronson RT, Dillon DA, Brugge JS. Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer. Breast Cancer Res. 2020 Nov 30;22(1):132. PMID: 33256808

196. Li CMC, Shapiro H, Tsiobikas C, Selfors LM, Chen H, Rosenbluth J, Moore K, Gupta KP, Gray GK, Oren Y, Steinbaugh MJ, Guerriero JL, Pinello L, Regev A, Brugge JS. Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing. Cell Rep . 2020 Dec 29;33(13):108566. PMID: 33378681

197. Dekkers JF, van Vliet EJ, Sachs N, Rosenbluth JM, Kopper O, Rebel HG, Wehrens EJ, Piani C, Visvader JE, Verissimo CS, Boj SF, Brugge JS, Clevers H, Rios AC. Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids. Nat Protoc . 2021 Apr;16(4):1936-1965. PMID: 33692550

198. Zoeller JJ, Press MF, Selfors LM, Dering H, Slamon DJ, Hurvitz SA, Brugge JS. Clinical evaluation of BCL-2/XL levels pre- and post- HER2-targeted therapy. PLoS One . 2021 May 5;16(5):e0251163. PMID: 33951110

199. Daniels VW, Zoeller JJ, van Gastel N, McQueeney KE, Parvin S, Potter DS, Fell GG, Ferreira VG, Yilma B, Gupta R, Spetz J, Bhola PD, Endress JE, Harris IS, Carrilho E, Sarosiek KA, Scadden DT, Brugge JS, Letai A. Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics. Sci Signal . 2021 Jun 8;14(686):eabc7405. PMID: 34103421

200. Oren Y, Tsabar M, Cuoco MS, Amir-Zilberstein L, Cabanos HF,  Hütter JC, Hu B, Thakore PI, Tabaka M, Fulco CP, Colgan W, Cuevas BM, Hurvitz SA, Slamon DJ, Deik A, Pierce KA, Clish C, Hata AN, Zaganjor E, Lahav G,  Politi K, Brugge JS, Regev A. Cycling cancer persister cells arise from lineages with distinct programs. Nature . 2021 Aug;596(7873):576-582. PMID: 34381210

201. Kuiken HJ, Dhakal S, Selfors LM, Friend CM, Zhang T, Callari M, Schackmann RCJ, Gray GK, Crowdis J, Bhang HEC, Baslan T, Stegmeier F, Gygi SP, Caldas C, Brugge JS. Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts. Oncogene . 2021 Oct 26. PMID: 34703030


Review Articles

1.  Brugge, J.S. and Chinkers, M.  Tyrosine specific protein kinases.  In: Annual Reports in Medicinal Chemistry, Vol. 18 (ed. H-J. Hess), Academic Press, New York, pp. 213-225 (1983).

2.  Brugge, J.S. Interaction of the Rous sarcoma virus protein pp60src with the cellular proteins pp50 and pp90.  In: Current Topics in Microbiology and Immunology, Vol. 123, Springer-Verlag, Berlin (1985).

3.  Brugge, J.S. The p35/p36 substrates of protein-tyrosine kinases as inhibitors of phospholipase A2.  Cell 46:149-150 (1986).

4.  Golden, A. and Brugge, J.S.  The cellular and viral src gene.  In: The Oncogene Handbook Vol. 7 (eds. E.P Reddy, A.M. Skalka, and T. Curran). Elsevier Science Publishers, Amsterdam (1988).

5.  Shattil, S.J. and Brugge, J.S.  Protein tyrosine phosphorylation and the adhesive functions of platelets.  Curr. Opin. Cell Biol., 3: 869-879 (1991).

6.  Clark, E., and Brugge, J.S.  Tyrosine phosphorylation in platelets and potential roles in intracellular signal transduction.  Trends in Cardiovascular Medicine, 3: 218-227 (1993).

7.  Brugge, J.S.  New intracellular targets for therapeutic drug design.  Science, 260: 918-919 (1993).

8.  Shattil, S.J., Ginsberg, M.H., Brugge, J.S.  Adhesive signaling in blood platelets.  Curr. Opin. Cell Biol., 6: 695-704 (1994).

9.  Clark, E.A., Shattil, S.J. and Brugge, J.S.  Regulation of protein tyrosine kinases in platelets.  Trends Biochem. Sci., 19: 464-469 (1994).

10.  Clark, E.A. and Brugge, J.S.  Integrin signal transduction pathways, the road taken.  Science, 268: 233-239 (1995).

11.  Clark, E.A. and Brugge, J.S.  Tyrosine Phosphorylation.  In:  Platelet Function and Signal Transduction:  A Practical Approach.  (Watson, S. and Authi, K., eds) Oxford University Press, Oxford, England (1996).

12.  Brugge, J.S., Clark, E.A., Shattil, S.J.  Protein Tyrosine Phosphorylation in Platelets.  In:  Advances in Molecular and Cell Biology, “The Platelet”.  (Bittar, E.E.ed) JAI Press, Greenwich, CT (1997).

13.  Bolen, J.B. and Brugge, J.S. Leukocyte protein tyrosine kinases: potential targets for drug discovery. Annual Review of Immunology, 15: 371-404 (1997).

14. Thomas, S. and Brugge, J.S. Cellular functions regulated by Src family kinases. Annual Review of Cell and Developmental Biology.  13:513-609 (1997).

15. Brugge, J.S.  Casting light on focal adhesions.  Nature Genetics 19: 309-311 (1998).

16. Brugge, J.S. and McCormick, F. Cell Regulation:  Intracellular Networking.  Current Opinion in Cell Biology, 11: 173-176 (1999).

17. Miranti, C. Brugge, J.S. Sensing the environment: a historical  perspective on integrin signal transduction. Nat Cell Biol. 4: E83-90.
18. Debnath, J, Muthuswamy, S.K., and Brugge, J.S. Morphogenesis And Oncogenesis Of MCF-10A Mammary Epithelial Acini Grown In Three-Dimensional Basement Membrane Cultures. Methods. Jul;30(3):256-68 (2003).

19. Seton-Rogers SE, Brugge JS. ErbB2 and TGF-beta: A Cooperative Role in Mammary Tumor Progression?  Cell Cycle 3(5):597-600 (2004).

20. Shaw KR, Wrobel CN, Brugge JS: Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis, J Mammary Gland Biol Neoplasia. Oct;9(4):297-310 (2004)

21. Debnath, J. and Brugge J.S. Modeling Epithelial Cancers in 3D Cultures, Nature Reviews Cancer 5: 675-688 (2005)

22. Walker SJ, Brugge JS. SePARating polarity and proliferation in ErbB2 oncogenesis. Nat Cell Biol 8 (11): 1220-2, 2006.

23. Carroll DK, Brugge JS, Attardi LD. p63, cell adhesion and survival. Cell Cycle 6 (3): 255-61, 2007.

24. Brugge, J.S., Hung, M.C., Mills, G.B.  A New Mutational aktivation in the PI3K Pathway, Cancer Cell 12, 2007, 10-13

25. Mouneimne G, Brugge JS. Tensins: a new switch in cell migration. Dev Cell 13 (3): 317-9, 2007.

26. Schafer ZT, Brugge JS. IL-6 involvement in epithelial cancers. J Clin Invest 117 (12): 3660-3, 2007.

27. Overholtzer M, Brugge JS. The cell biology of cell-in-cell structures. Nat Rev Mol Cell Biol. 2008;9(10):796-809.

28. Mailleux AA, Overholtzer M, Brugge JS. Entosis, a cell death process related to cell cannibalism between tumor cells. Med Sci (Paris) 24 (3): 246-248, 2008.

29. Mailleux AA, Overholtzer M, Brugge JS. Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle 7 (1): 57-62, 2008.

30. Mouneimne G, Brugge JS. YB-1 translational control of epithelial-mesenchyme transition. Cancer Cell (2009) vol. 15 (5) pp. 357-9

31. Iwanicki MP, Brugge JS. Transcriptional regulation of metastatic [Id]entity by KLF17. Genome Biol. 2009;10(11):244.

32. Leung, C.T., and Brugge, J.S. (2009). Tumor self-seeding: bidirectional flow of tumor cells. Cell 139, 1226-1228.

33. Ng MR, Brugge JS. A stiff blow from the stroma: collagen crosslinking drives tumor progression. Cancer Cell. 2009;16(6):455-7.

34. Harrison SC, Brugge JS. Mechanistic biology in the next quarter century. Mol Biol Cell. 2010;21(22):3799-800. PMCID: 2982119.

35. Grassian AR, Coloff JL, Brugge JS. Extracellular Matrix Regulation of Metabolism and Implications for Turmorigenesis. Cold Spring Harb Symp Quant Biol. 2011 Nov 21. [Epub ahead of print]
PMID: 22105806.

36. Brugge JS. Rab25 Mediates Integrin Recycling for Tumor Cell Migration in 3D. Dev Cell. 2011 Nov 15;21(5):e1. PMID: 22075151

37. Albeck JG, Brugge JS. Uncovering a tumor suppressor for triple-negative breast cancers. Cell. 2011;144(5):638-40.

38. Gallegos L, Ng MR, Brugge JS. The myosin-II-responsive focal adhesion proteome: a tour de force? Nat Cell Biol. 2011;13(4):344-6.

39. Brugge JS. Into the deep: Refocusing on 3D. Nat Cell Biol. 2012;14(4):332.


Chapters in Books

1. Yonemoto, W., Lipsich, L., Darrow, D. and Brugge, J.S. An analysis of the interaction of the Rous sarcoma virus transforming protein, pp60src, with a major heat shock protein. In: Heat Shock Proteins from Bacteria to Man (ed. Schlesinger, M.J., Ashburner, M., Tisseries, A.) Cold Spring Harbor Laboratory (1982).

2. Brugge, J.S., Darrow, D., Lipsich, L.A. and Yonemoto, W. The association of the transforming protein of Rous sarcoma virus with two cellular phosphoproteins. In: Oncogenes: Evaluation of Basic Findings and Clinical Potential (ed. R. Rauscher) Alan Liss, New York, pp. 135-148 (1982).

3. Brugge, J.S., Yonemoto, W., Lipsich, L. and Darrow, D. Studies on the interaction between the transforming proteins of avian sarcoma viruses and two cellular proteins. "Tumor Viruses and Differentiation", (ed. Scolnick, E. and Levine, A.), Alan Liss, New York, pp. 399-410 (1983).

4. Lipsich, L.A., Yonemoto, W., Bolen, J., Israel, M., and Brugge, J.S. Structural and functional studies on the Rous sarcoma virus transforming protein. In: Cancer Cells 2: Oncogenes and Viral Genes (eds. Van de Woude, G.F., Levine, A.J., Topp, W.C., Watson, J.D.) Cold Spring Harbor, New York, pp. 43-52 (1984).

5. Yonemoto, W., Bolen, J.B., Israel, M.A., Lipsich, L. and Brugge, J.S. Use of monoclonal antibodies to probe the functional activity of the cellular src gene product in polyoma virus transformed cells. In: Monoclonal Antibodies and Cancer Therapy, Vol. 27, 551-565 (ed. R.A. Reisfeld and S. Sell (1985).

6. Coussens, P.M. and Brugge, J.S. Comparison of the structural and functional properties of the viral and cellular and src gene products. In: Induction and Recognition of the Transformed Cell (Eds. M.I. Greene and T. Hamaoka), Plenum Press, New York (1986).

7. Brugge, J.S. Regulation of the expression of the cellular src proto- oncogene product pp. 401-415 (eds. N.O. Kjeldgaard and J. Forchhammer). Alfred Benson Symposium 24 on Viral Carcinogenesis (1987).

8. Brugge, J.S., Yonemoto, W., Lustig, A., and Golden, A. Investigations of the expression of the cellular src gene product, pp. 241-252. In Oncogenes and Cancer. Proceedings of the International Symposium of the Princess Takamatsu Cancer Research Fund, S.A. Aaronson et al. (Eds.), Japan Sci. Soc. Press, Tokyo/VNU Press, Utrecht, (1987).

9. Brugge, J.S. Expression of the c-src proto-oncogene product in neural cells, pp. 213-226 In: NATO Research Workshop on Cellular and Molecular Aspects of Neural Development and Regeneration, Vol. 22 (A. Gorio et al., eds.) Springer Verlag (Heidelberg) (1988).

10. Brugge, J.S. and Levy, J.B. Investigations of a variant form of the tyrosine protein kinase, pp60c-src in neuronal cells. In: "Protein Phosphorylation and Neuronal Function, (eds. E. Costa and E. Barnard) Raven Press, NY (1989).

11. Grassian AR, Coloff JL, Brugge JS. Extracellular Matrix Regulation of Metabolism and Implications for Tumorigenesis. Cold Spring Harbor Symposia on Quantitative Biology. 2011



Brugge, J., Curran, T., Harlow, E., McCormick, F. Origins of Human Cancer: A Comprehensive Review. Cold Spring Harbor Press, New York.